Guanylin Peptides
Overview
Guanylin is a 15-amino acid peptide secreted by goblet cells in the colon. It functions as an endogenous agonist of the guanylyl cyclase C (GC-C) receptor, regulating electrolyte and water transport across intestinal and renal epithelia. Upon receptor binding, guanylin increases intracellular cGMP levels, inducing chloride secretion and reducing fluid absorption — a mechanism central to intestinal fluid homeostasis.
Key Features
- Human, rat/mouse guanylin, uroguanylin, and renoguanylin variants available
- Disulfide bridge-constrained peptides (Cys⁴-Cys¹², Cys⁷-Cys¹⁵) with correct folding
- ≥95% purity (HPLC) for reliable receptor activation studies
Product Specifications
| Parameter | Specification |
|---|---|
| Purity | ≥95% or ≥98% (HPLC verified) |
| Form | Lyophilized powder |
| Storage | -20°C, desiccated, protected from light |
| Research Use Only | Yes |
| Purity | ≥95% or ≥98% (HPLC verified) |
| Form | Lyophilized powder |
| Storage | -20°C, desiccated, protected from light |
| Research Use Only | Yes |