MIF-1 (Melanostatin)
Overview
MIF-1 (Melanocyte-Stimulating Hormone-Release Inhibiting Factor), also known as Melanostatin or Melanocyte-inhibiting factor, is an endogenous tripeptide (Pro-Leu-Gly-NH₂) derived from the hormone oxytocin. Despite its origin, MIF-1 exhibits pharmacological actions distinct from oxytocin, functioning as a positive allosteric modulator of D₂ and D₄ dopamine receptor subtypes and blocking opioid receptor activation while potentiating melatonin activity.
Key Features
- Endogenous tripeptide (H-Pro-Leu-Gly-NH₂, CAS 2002-44-0) with multi-target neuromodulatory activity
- Available as native MIF-1 and peptide analogs including (Tyr⁰)-MIF-1, (Tyr⁰,Trp²)-MIF-1, and (D-Leu²)-MIF-1
- Custom synthesis with ≥95% purity, verified by HPLC
Product Specifications
| Parameter | Specification |
|---|---|
| Purity | ≥95% or ≥98% (HPLC verified) |
| Form | Lyophilized powder |
| Storage | -20°C, desiccated, protected from light |
| Research Use Only | Yes |
| Purity | ≥95% or ≥98% (HPLC verified) |
| Form | Lyophilized powder |
| Storage | -20°C, desiccated, protected from light |
| Research Use Only | Yes |