Neurokinin Peptides
Overview
Neurokinins are a class of tachykinin peptide neurotransmitters broadly distributed in the central nervous system. The family includes Substance P (SP), Neurokinin A (NKA, also known as Substance K), and Neurokinin B (NKB), each binding with distinct affinity to three G-protein-coupled receptors: NK₁, NK₂, and NK₃. These neuropeptides regulate pain transmission, smooth muscle contraction, inflammation, and neuroendocrine function.
Key Features
- Complete neurokinin catalog: NKA/Substance K (HKTDSFVGLM-NH₂, CAS 86933-74-6), NKB (DMHDFFVGLM-NH₂, CAS 86933-75-7), and biologically active fragments
- Extensive analog collection including β-Ala⁸ substitutions, D-Trp⁶˒⁸˒⁹ variants, and biotinylated forms for receptor binding assays
- Custom synthesis with ≥95% purity, verified by HPLC
Product Specifications
| Parameter | Specification |
|---|---|
| Purity | ≥95% or ≥98% (HPLC verified) |
| Form | Lyophilized powder |
| Storage | -20°C, desiccated, protected from light |
| Research Use Only | Yes |
| Purity | ≥95% or ≥98% (HPLC verified) |
| Form | Lyophilized powder |
| Storage | -20°C, desiccated, protected from light |
| Research Use Only | Yes |